Importance of Sequencing To Determine Functional bla TEM Variants
نویسندگان
چکیده
منابع مشابه
A bla(TEM-1b)-derived TEM-6 beta-lactamase: a case of convergent evolution.
Since the first communication describing an organism that produces an enzyme capable of hydrolyzing extended-spectrum cephalosporins (5, 6), several outbreaks of Enterobacte-riaceae resistant to oxyimino--lactams have been reported. In these cases, the adopted survival strategy of bacteria challenged by the introduction of aztreonam, cefotaxime, ceftazi-dime, and other oxyimino--lactams was t...
متن کاملdetection of bla tem and bla shvgenes among clinical isolates of e. coli from tehran hospitals
background and objectives: the pathogenic strains of escherichia coli cause severe septicemia, urinary tract infection and wound sepsis. resistance of this organism to the expanded-spectrum cephalosporins occurs via the production of extended-spectrum β-lactamases (esbls) such as tem and shv. these enzymes hydrolyze oxyimino cephalosporins (cefotaxime, ceftazidime) and monobactams (aztreonam). ...
متن کاملSequencing rare and common APOL1 coding variants to determine kidney disease risk
A third of African Americans with sporadic focal segmental glomerulosclerosis (FSGS) or HIV-associated nephropathy (HIVAN) do not carry APOL1 renal risk genotypes. This raises the possibility that other APOL1 variants may contribute to kidney disease. To address this question, we sequenced all APOL1 exons in 1437 Americans of African and European descent, including 464 patients with biopsy-prov...
متن کاملfrequency of bla tem, bla shv, bla ctx-m, and qnra among escherichia coli isolated from urinary tract infection
conclusions considering the high prevalence of esbl genes (bla ctx-m, 87%; and bla tem, 82%), fluoroquinolones may be used as an alternative drug in treatment, although resistance to this family is increasing as well. as a result, this increasing trend should be prevented using appropriate guidelines for prescription. background escherichia coli is the most important as well as the most common ...
متن کاملMolecular Characterization and In Silico Analysis of Naturally Occurring TEM Beta-Lactamase Variants among Pathogenic Enterobacteriaceae Infecting Indian Patients
Cephalosporin resistance, particularly due to bla(TEM) encoded β-lactamases, among Enterobacteriaceae is, though, an increasing public health problem in India; their circulating genetic variants remain unknown. The present study deals with determination of bla(TEM) variants among 134 pathogenic Enterobacteriaceae of Indian origin. Their resistance profile against 3rd generation cephalosporins w...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2017
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00237-17